539
www.dermatologiepropraxi.cz451480400107651332012142633073344084494765225425906406597037527798268779039459851004102010601099
681828020012657116
DERMATOLOGIE3418040010758102149221276314375417477536557600
PRO963804001074591154
PRAXI1138804001074591148201221
/14058040010732
Dermatol.14828040010758103129203244271318338353
praxi.1855804001075077118158177193
2025;19(2):68-712068804001074487128172185223261284327349364409454482521562
/26758040010732
PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
Autologní34136001063877110148180219259300318
transplantace67436001063066108149181216247288330362398431463
progenitorových115336001063368109149180222239271310346387424463496537
buněk170536001063475116148184
v1905360010636
léčbě19573600106296196132164
androgenní213736001063879118154195235266308349367
alopecie251936001063869108143175210227259
u2794360010639
mužů284836001065293125166
i3030360010615
žen306036001063163104
Autologní340920029815729338051758272086010001064
transplantace145392002988818030344354568875387910181103123013371461
progenitorových296292002981442343725126377788429291066115612931415154616501790
buněk48019200298143282422547678
v34011800298127
léčbě5161180029866191300443570
androgenní113411800298127266408498636776901104211811245
alopecie242811800298127191329471597706771896
u337311800298140
mužů356111800298206345457594
i42041180029866
žen431811800298113238379
MUDr.3401580013793168245287311
Samuel6731580013759118212276335366
Pavlík10611580013764121178208238300
Medizinische3401740013388144206231278303364389431480540596
Universität9591740013371131156209262298342367403456491
Wien14731740013393120174235
a17311740013354
Klinika1808174001335986111171196247301
Dermarevolta,21321740013374129165256309344399450509535571624647
Vídeň,2802174001336286148203263286
Rakousko31111740013359112163222282325376434
Androgenní3402250012161117175209264322373430486510
alopecie877225001214872129187239285309361
je1264225001212476
nejčastější13662250012156107132178228268303353377418442
příčinou1834225001215791115161185241297353
vypadávání2214225001214899158208266315362412468492
vlasů2733225001214873122162217
u29772250012155
mužů30582250012184139183239
i33242250012123
žen.3374225001214394150172
Tento3573225001215094151184240
stav340239001214076126175
je546239001212476
způsoben6532390012144103160201258317370427
genetickými11112390012157109167219254279325373426512537
predispozicemi1679239001215792144203228268327385428453500551636661
a23712390012149
vlivem245123900121497499149200286
androgenů,27682390012148105164198255313366423480502
zejména3301239001214395120206258316366
dihydrotestosteronu36982390012157813402530012155102159192248282332372407462502537588622677734790
(DHT),1152253001212895161213245265
který1439253001214784134168219
negativně16802530012156107165214248272321378430
ovlivňuje21322530012155103128152201258314338390
vlasové2544253001214873122162219267317
folikuly2883253001212985110134182238263311
a32162530012148
vede3287253001214898156208
k35172530012147
jejich3586253001212476100125170226
postupné3402670012157113153188244301358409
miniaturizaci.7692670012183107163187236269325358382426476522546567
Mezi13562670012180132176200
běžné15762670012157108152209260
léčebné1856267001212374121170228285336
možnosti22122670012183139182238294334368392
patří26242670012157106140173197
farmakologická2841267001212979112197245293347372428486510555602652
terapie3513267001213383117166224248299
(např.340281001212882131189222239
finasterid603281001213057113162202237287321346403
nebo10312810012155107165222
minoxidil)12772810012183108164220266291349373397426
a17282810012148
chirurgické18002810012145101125159215248305329375423473
metody,22972810012183135169224283331348
jako2670281001212473121176
je2870281001212476
transplantace2970281001213367116173213270295344400434484529579
vlasů.3574281001214873122162217239
Novou3402950012165121169223279
a6382950012148
slibnou70629500121396387143200255311
metodou10362950012183134168223280336392
je1447295001212475
autologní15412950012148103137191216272329384408
transplantace1969295001213265114170210266291340395428477523572
progenitorových2561295001215690145202253309332366420454509556608652707
buněk,32882950012156112168219266290
která3597295001214783133167216
představuje340309001215791141200240275325372429454505
miniinvazivní8703090012184108164188212269316365410434484541565
zákrok1460309001214394141177232280
využívající1766309001214899156200225274323348372418442
regenerační2233309001213384141193249301335384430486510
schopnosti2769309001213985141197255312368408443467
vlastních3262309001214873122162197253277323379
buněk366630900121571133403230012155107155
pacienta.5213230012157107153177228285318368390
Tento938323001214994151184239
přístup1204323001215790115155190246303
může15343230012183139183234
významně17943230012148100146202252336392443
podpořit22643230012157114172230286320345379
obnovu26693230012155113170226274331
vlasových3026323001214874123163219267319364420
folikulů,3472323001212985110134182238263318340
zlepšit340337001214367119177217241275
kvalitu635337001214799149173197231287
vlasů942337001214873122163218
a11803370012148
oddálit12483370012155114171220245269303
další15713370012156105130170194
progresi1785337001215791146204238288329353
onemocnění,21583370012155112163248304350407458514539560
a27383370012149
to2807337001213388
s29153370012140
minimálním29753370012183107164188272321345401425510
rizikem3505337001213357101125173223308
vedlejších340351001214898156181232257297321367423
účinků.7863510012155101125181229285307
Klíčová340367001246291119164222275328
slova:695367001244372131183236262
alopecie,986368001214872127185236282305356376
folikuly,1390368001212985109132179235258306322
farmakologická1740368001213079111196244291345369424481505550596646
terapie,2414368001213383116165222245296316
progenitorové2758368001215791145202253309332365420453508555605
buňky,33913680012157113168215266282
dihydrotestosteron.37013680012157803403820012155101157189244277326365399453492526576609663719740
Autologous3404090012466123161219247305365423482526
progenitor887409001245998156216269329357394452491
cell1398409001244598127155
transplantation1573409001243676128188231292320374433470523560589647706
in2299409001242887
the2406409001243797150
treatment2576409001243776130183220308361421457
of3054409001245792
androgenetic31664090012453112172211270329382442495533562607
alopecia340423001245381139200253300328381
in741423001242887
men8484230012486140199
and10674230012453112173
women12604230012476133220273333
Androgenetic3404410012163120179213269328380438490525549595
alopecia965441001215074131190243291315364
is1359441001212465
the1454441001213491143
most16274410012185143183219
common18754410012146102188274331389
cause2294441001214696153194246
of2570441001215686
hair26864410012157107131165
loss2881441001212481122163
in3073441001212481
both31844410012159116151208
men34214410012186138196
and36474410012149106165
women.3404550012174128212262318339
This7004550012149106129168
condition889455001214598154211234267290345401
results1311455001213282122176200233273
from1605455001212963117201
genetic18274550012156106162212246269313
predispositions2161455001215790140197220260316372411434467490545601640
and28224550012148103160
the3003455001213388138
influence3162455001212479108134189239295340389
of3572455001215584
androgens,36774550012148103340469001215689143199249305343364
particularly7224690012157105138173196241295318366398422469
dihydrotestosterone1209469001215679134179234267321354403442476529568602651684738793844
(DHT),2070469001212994159210240259
which23474690012173128151196251
adversely26154690012148105153202234275325349396
affects3028469001214877110160205240281
hair33264690012156103126159
follicles3502469001212984108131154198221271310
and3404830012148103160
leads526483001212474122179218
to771483001213387
their884483001213388139162195
gradual1105483001215688137194248296320
miniaturization.14514830012183107162185233265320353376419469501525580635656
Conventional21344830012158111167213262318350374429484532556
treatment2716483001213366115164196279330385418
options31604830012155112145168223279318
include3504483001212479124147202258309
pharmacological3404970012157113161193276324369423447502558581626674698
therapy1056497001213388138171219276322
(e.g.,139649700121287595150171192
finasteride1606497001212955110158197231280313336393443
or2067497001215588
minoxidil)21734970012183106161216261285341364387415
and26064970012148103160
surgical2784497001213994126182205249298321
methods31234970012183134167222277334373
such3514497001214094139194
as3726497001214887
hair3405110012155103127159
transplantation.524511001213366114169208265289337392424473506529584639661
A12105110012161
novel12965110012155110157206230
and15515110012149104160
promising1736511001215790145228252291314369425
approach21865110012148105162195249298343398
is2609511001212362
autologous26965110012148103136190214269326381436476
progenitor3196511001215790145201252307331364418451
cell3672511001214493117140
transplantation,340525001213366114169208265289337392424473506529584640660
a10205250012148
minimally10885250012183107162185268316340363410
invasive1518525001212378125173212235284333
procedure1870525001215790145190239297351384434
that2323525001213489137169
utilizes2512525001215588111134157200250290
the2821525001213489139
regenerative2980525001213282139189245296328377409432481530
potential35305250012156112145194250340539001213356104127
of488539001215584
the592539001213489139
patient’s7525390012157105138161211267299323359
own11325390012155128184
cells.1336539001214594118141180202
This15585390012150106129168
method17475390012183134167222277335
has21025390012156104143
the2265539001213389139
potential24245390012157113146195251283306354378
to2822539001213387
significantly2930539001213962118174197226252297346401433456504
enhance34545390012151106161209265310359
hair3405530012155103127159
follicle524553001212984108131154199222272
regeneration,821553001213383139190245296329377410433488543564
improve14105530012123106163196251298347
hair17825530012155103126159
quality,19655530012157111159183206239289305
and22945530012149104161
delay24795530012157107131179225
further2728553001212985118154209259292
progression3045553001215790144201234283323362385440496
of3565553001215584
the3674553001213388139
condition,340567001214599154211234267290345401422
all78356700121487295
while8995670012174129152176226
minimizing11465670012184107162185268292334358413469
the1636567001213388139
risk179656700121335695142
of1959567001215584
adverse20655670012148104153202235275326
effects.2412567001215080112163208244284306
Key3405830012462114166
words:5335830012476134173234278304
alopecia,866584001214872128185237283306354376
follicles,1270584001213085109133156201224275315336
pharmacological16355840012157114162195279328373427451507564587633682705
therapy,2369584001213389140173222279326342
progenitor2739584001215891146203254310333367421454
cells,3222584001214594119142181203
dihydrotestosterone.3453584001215780136182238271326340598001213382122156210249283332365420475526546
Úvod3406470014780142208279
Androgenní4806640010955106157187237289335385436457
alopecie963664001094365115167214255277322
(AGA),1311664001092681137193218236
známá1572664001093990133209253
také1851664001093074117161
jako340678001092266109158
genetická524678001095096147193224246287329374
alopecie924678001094465116168215257278324
s12746780010936
charakteristickým1335678001094191135165209252285330361383418450471512555601677
vzorem,340692001094485135166212288308
je674692001092268
progresivní768692001095282133185215261297319363415436
stav,1230692001093668113156171
který1427692001094275121151198
postihuje16506920010952104140171193243294316362
muže3407060010975125164209
i5747060010921
ženy,619706001093984134176191
přičemž834706001095181103143188263302
celoživotní1161706001094085107157195216260309339389410
prevalence1596706001095181126169213235281331372416
dosahuje3407200010950100135179229278300345
přibližně701720001095180101152174195233283328
501045720001094691
%11527200010971
u12397200010949
mužů13047200010974124162212
a15317200010944
významného15907200010943891291792232973473923407340010950100
procenta465734001095282131173217268297342
u8327340010950
žen.907734001093984135154
Projevuje1086734001094877127149194238288310356
se1467734001093682
postupným15747340010951102138169219270321362438
řídnutím340748001092951102152202232253328
vlasů686748001094365109144194
v8977480010943
určitých958748001095079119140170216255305
oblastech12817480010949101123167202233278319369
v16687480010943
důsledku17297480010951100136157203255340762001094292
miniaturizace453762001097596146167211240290320341380425466511
vlasových984762001094365109144194237283323373
folikulů.137776200109267698119162212233283302
Hlavním1699762001095980124166217238313
faktorem340776001092671113146195225270346
tohoto704776001093079129179209258
stavu980776001093667111153204
je1202776001092268
dihydrotestosteron1288776001095172122163214243293323367403434483519550595624674725
(DHT),2140650001092583140185212228
androgen,2382650001094391141170217267311360378
který2775650001094172116144188
se2978650001093579
váže3071650001094385123167
na3252650001094991
receptory3358650001092972112155205234282311355
ve3727650001094286
vlasových2140664001094365109144195237283323373
folikulech,253266400109267698119162212233279320370390
což2941664001094089127
vede3087664001094388140185
k32916640010943
jejich335366400109216789110151201
zmenšení357366400109381141602102140678001093579128149
a23046780010942
snížené2361678001093583104142186235279
schopnosti2655678001093575123172222271320354384404
produkovat3074678001095179128178226267315356399427
zdravou3516678001093888116159200248296
vlasovou2140692001094365109144195237286336
matrix.25006920010975118148178199242262
Ačkoli2785692001095594136185207228
není3036692001095096147168
tento3227692001093074125154203
stav3454692001093566110153
život3630692001093860104153182
ohrožující,21407060010949100130179217267289310351372391
výrazně2551706001094389120164203253299
ovlivňuje2870706001094992114135179230279301347
psychickou3237706001095187130170220241282324373423
pohodu,3680706001095110221407200010950100152201221
sebevědomí2385720001093581133179222267319369444466
a28757200010943
celkovou2942720001094185107149198241290340
kvalitu3306720001094389133154175206255
života3586720001093860103152182227
jedince.2140734001092268119141191232276295
U22807480010958
mužů23647480010975125164214
se2603748001093682
AGA27107480010955112168
obvykle29037480010950101145191234257303
projevuje3231748001095181131153199242293314360
ustupující361774800109498511616621407620010951102124145186207
linií237376200109214293114135
vlasů2534762001094365109145195
a27547620010944
řídnutím2823762001093052103153203234255330
na3179762001095094
temeni3299762001093075150197247269
hlavy,3593762001095072116158204219
zatímco2140776001094087118140219262312
u24817760010951
žen2560776001093987139
se2728776001093684
vyskytuje2840776001094593131175223257309332380
difuzní3248776001095275103156197249272
řídnutí3548776001093053106159210242265
DECLARATIONS:4070227008648871301662142563043393604124625014571227008514
Declaration406924100874987120141179207245272292334376
of445924100874166
originality:45392410087406888131151193231252272299338358
The406925200853473109
manuscript418925200855791130168195227249266306329
is452925200851644
original45842520085386178117133172205222
and481725200853472112
has49402520085387299
not50512520085387699
been516225200853975110149
published532225200854078118135151178217252292
or406926300853862
submitted414626300852867108167184208234269310
elsewhere.44712630085355381117169209246269305320
Ethical406927700873764107127160198219
principles43022770087427090132165185229249288319
compliance:463627700873172134177198218256298331369388
The406928800853678116
authors420628800853475100142183208238
attest44652880085356087124154179
that466528800852465101126
their481228800852465103121146
study49792880085295596138173
was517428800855389118
approved531428800853477119144185220257300
by406929900854073
the41592990085236399
local42752990085165689124141
Ethical44332990085345898115147182199
Committee464929900854179139198215239265300337
and500229900853474114
is513329900851745
in519529900851656
compliance526729900853270130170188205239279311347
with40693100085537298140
human423731000854081143180221
studies44873100085285496139157195226
and474131000853577119
animal48893100085347695156193212
welfare512931000855391110133170196233
regulations53913100085236110414516420140693210085234080120148
of423732100853859
the43163210085236399
authors’44353210085347397136176200229244
institutions46993210085175684109126150189214231270310338
as505732100853462
well513932100855187105122
as528132100853362
with53623210085526994133
the55153210085236399
World406933200856099124142184
Medical427433200855795137154188224242
Association453633200854474104144178196231256273314355
Declaration491233200854785119136172196232257274315356
of528933200853961
Helsinki537033200854785103132150190225244
on406934300853878
Ethical41663430085345898115147182199
Principles43843430085376178117150167207225261290
for46923430085216084
Medical479534300855693134151183218235
Research504934300853874102139173197229268
Involving53363430085165690128146181198238278
Human406935400854685145179219
Subjects430835400853474114132168201227256
adopted458435400853474114155179215256
by486035400853973
the49533540085236399
18th507235400853669514335400501437
WMA5199354008559116160
General537935400854582122158182217235
Assembly406936500854475105143204247266302
in439436500851758
Helsinki,447536500854785104134152193228248264
Finland,47623650085355394113149190232249
in503436500851758
June511636500852668109147
1964,528636500853771110150166
with54763650085537197138
subsequent406937600852867107136172213252288328352
amendments,443837600853493130169210269305345369398414
as486937600853462
well494937600855287105122
as508937600853362
with51683760085526993133
the53193760085236299
ICMJE543537600851759116143179
Recommendations406938700853977112153216278317359402439465483525568598
for46993870085216389
the481938700852466105
Conduct,495538700854283125168210245272290
Reporting,527638700853978121164190218236278321338
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