Dermatol. praxi. 2025;19(3):122-125 | DOI: 10.36290/der.2025.022

Behçet's disease: How skin manifestations reveal a rare disease

MUDr. Monika Baláž1, 2, MUDr. Mirka Martincová1, 2, MUDr. Martin Tichý, Ph.D.1, 2, MUDr. Tomáš Tichý3
1 Klinika chorob kožních a pohlavních, Lékařská fakulta, Univerzita Palackého v Olomouci
2 Klinika chorob kožních a pohlavních, Fakultní nemocnice Olomouc
3 Ústav klinické a molekulární patologie, Fakultní nemocnice Olomouc

Behçet's disease is a multisystem disease with a significant heterogeneity of clinical presentation that often manifests with skin and mucosal lesions. The present case report underscores the importance of early dermatological evaluation in a patient with atypical and rapidly progressing skin manifestations, which played a key role in establishing the diagnosis of Behçet's disease.

Keywords: Behçet's disease, vasculitis, pathergy test, mucocutaneous manifestations, oral ulceration, genital ulceration.

Accepted: September 23, 2025; Published: October 2, 2025  Show citation

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Baláž M, Martincová M, Tichý M, Tichý T. Behçet's disease: How skin manifestations reveal a rare disease. Dermatol. praxi. 2025;19(3):122-125. doi: 10.36290/der.2025.022.
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    References

    1. Emmi G, Bettiol A, Hatemi G, et al. Behçet's syndrome. Lancet. 2024;403(10431):1093-1108. Go to original source... Go to PubMed...
    2. Bulur I, Onder M. Behçet disease: New aspects. Clin Dermatol. 2017;35(5):421-434. Go to original source... Go to PubMed...
    3. Lavalle S, Caruso S, Foti R, et al. Behçet's Disease, Pathogenesis, Clinical Features, and Treatment Approaches: A Comprehensive Review. Medicina (Kaunas). 2024;60(4):562. Go to original source... Go to PubMed...
    4. Davatchi F, Chams-Davatchi C, Shams H, et al. Behcet's disease: epidemiology, clinical manifestations, and diagnosis. Expert Rev Clin Immunol. 2017;13(1):57-65. Go to original source... Go to PubMed...
    5. Grzybowski A, Pawlikowska-Łagód K, Altenburg A, et al. Adamantiades-Behçet disease: Between dermatology and ophthalmology. Clin Dermatol. 2023;41(4):469-475. Go to original source... Go to PubMed...
    6. Ksiaa I, Abroug N, Kechida M, et al. Eye and Behçet's disease. J Fr Ophtalmol. 2019;42(4):133-146. Go to original source... Go to PubMed...
    7. Karadag O, Bolek EC. Management of Behcet's syndrome. Rheumatology (Oxford). 2020;59(3):108-117. Go to original source... Go to PubMed...
    8. International Team for the Revision of the International Criteria for Behçet's Disease (ITR-ICBD). The International Criteria for Behçet's Disease (ICBD): a collaborative study of 27 coun­tries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol. 2014;28(3):338-47.
    9. Vitale A, Berlengiero V, Caggiano V, et al. The diagnostic role of pathergy test in patients with Behçet's disease from the Western Europe. Intern Emerg Med. 2023;18(1):77-83. Go to original source... Go to PubMed...
    10. Kutlubay Z, Tüzün Y, Wolf R. The Pathergy Test as a Diagnostic Tool. Skinmed. 2017;15(2):97-104.
    11. Chan WP, Lee HS. Combination therapy with infliximab and methotrexate in recalcitrant mucocutaneous Behçet disease. Cutis. 2012;89(4):185-90.

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