Dermatol. praxi. 2023;17(2):104-107
Outbreaking discovery: what if sking aged twice slower?
- NAOS Scientific Manager Czech Republic & Slovakia
The biological evolution of some living organisms is opening up a new path: understanding why and how we age. Organisms capable of withstanding extreme conditions are examples of perfect evolution in terms of biological robustness: their genetic adaptation by selection has helped transform a hostile environment into an optimal environment. When the extremophiles such as Deinococcus radiodurans or Arthrobacter agilis bacterias are exposed to radiation, they can transition from a "clinical death" state to a "resurrection" process through self-repair. It has been shown that ageing and age-related diseases (ARD) share the same cause: protein damage. Especially, protein carbonylation can be considered as marker and accelerator of ageing and it is common marker of most ARD including Alzheimer and Parkinson diseases, diabetes, psoriasis, and skin cancer. Current research is promising and may open new therapeutic approaches and perspectives by targeting proteome protection.
Keywords: age, age-related diseases, skin, longevity, chaperon.
Published: June 7, 2023 Show citation
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