Dermatol. praxi. 2023;17(3):163-166 | DOI: 10.36290/der.2023.032
Case report - pemphigus foliaceus
- Kožnî oddělenî Fakultnî nemocnice Ostrava
Pemphigus foliaceus is relatively rare subtype of pemphigus, grouped within the mucocutaneous bullous diseases. These autoimmune blistering disorders are characterized by the presence of circulating antibodies against desmogleins, in structure of epidermal intercellular adhesions. Depending on the subtype of antibody present, these diseases can manifest with mucosal, mucocutaneous, or cutaneous presentation. Clinical manifestation and localization of skin lesions are unique for each of the subtypes of pemphigus, which, supported by histopathological findings and direct immunofluorescence, provide accurate diagnostic conclusion. In this case-report, author describes typical case of pemphigus foliaceus, successfully treated by immunosuppressants with great therapeutical outcome.
Keywords: bullous dermatosis, pemphigus foliaceus, acantholysis, desmoglein-1, direct immunofluorescence.
Accepted: October 2, 2023; Published: October 3, 2023 Show citation
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