Differential diagnosis of paraviral and toxic allergy exanthema in childhood

MUDr. Blanka Pinková, Ph.D.

Dermatol. praxi. 2024;18(1):170-172 | DOI: 10.36290/der.2024.003  

Exanthems in childhood are common and usually proceed without complications. There are many causes, which include mainly viruses, less often bacterial toxins, drugs, allergens and other diseases. Viral exanthema often occurs during a viral infection; it can mimic drug exanthema and in 10% of cases is seen as a drug allergy.

Rozhádané sestry a medicína

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2024;18(1):3  

Bacterial skin infection II. - infection induced by gram-negative bacteria

doc. MUDr. Ondřej Kodet, Ph.D.

Dermatol. praxi. 2024;18(1):5-9 | DOI: 10.36290/der.2024.001  

This review provides a brief overview of skin bacterial infections caused by gram-negative bacteria. These infections are less common and can have a rich clinical picture and differential diagnosis. Pseudomonas aeruginosa infection is among the most common skin infections caused by gram-negative bacteria. Among other infections, we can mention manifestations in severe acute, but also chronic, meningococcal infections, or skin lesions caused by the bacterium Bartonella henselae.

Photoprotection 2024

doc. MUDr. Karel Ettler, CSc.

Dermatol. praxi. 2024;18(1):10-13 | DOI: 10.36290/der.2024.002  

Sunlight, and especially its ultraviolet part, can damage children's skin with acute burns, and chronically in adults with photoaging and/or skin cancer. The intensity and duration of exposure are important, but also the characteristics (phototype) of the irradiated skin. Natural photoprotection can be strengthened by behavior modification, appropriate clothing and sunscreens (new trends in the development of sunscreens are also presented). After solar damage, it is necessary to treat the skin and definitely not to continue sunbathing. With normal use of sunscreens, there is usually no risk of vitamin D deficiency.

Drug hypersensitivity reactions

MUDr. Mojmír Račanský

Dermatol. praxi. 2024;18(1):19-23 | DOI: 10.36290/der.2024.004  

Drug hypersensitivity reactions are a healthcare problem with rising incidence. Adverse events diagnostic or therapeutical drugs could negatively affect patients' quality of life and increase healthcare costs. The first signs of drug hypersensitivity reactions involve skin or mucosal surfaces. Skin symptoms like acute urticaria or angioedemas and delayed reaction with maculopapular eruptions are well described. Those conditions could be the initial step to life-threatening reactions like anaphylaxis or severe cutaneous adverse reactions - Steven-Jones Syndrome, for example. This summary brings the current view on drug hypersensitivity symptoms, diagnostics...

Treatment of superficial wounds, ulcerations and leions on male genitalia

Mgr. Markéta Koutná, Ph.D.

Dermatol. praxi. 2024;18(1):24-27  

This paper focuses on superficial wounds and ulcerations of male genitalia, which often arise as a result of decompesation of the patien'ts health state in the conditions of intensive care. It presents possible care and treatment using moist wound healing method with selected therapeutic dressings. The artical can not include all available dressings. The author is aware of the fact, that local treatment can also be carried out using magistraliter preparation by a specialist in the field of a dermatology. The aim of the paper is to present care and treatment procedures that can be carried out in common conditions in hospital, outpatient as well as at...

Mechanisms of resistance to melanoma immunotherapy

MUDr. Linda Řandová, doc. MUDr. Ondřej Kodet, Ph.D.

Dermatol. praxi. 2024;18(1):28-34  

The treatment of melanoma has seen significant progress over the past 12 years. Its basis is immunotherapy using check-point inhibitors. Unfortunately, despite the long-term therapeutic response that can be achieved, many patients experience lower rates of therapeutic responses and failure with this form of treatment even after an initial good treatment response. These treatment complications are the subject of many studies that document individual mechanisms of primary and secondary resistance to melanoma immunotherapy. The study comprehensively describes contemporary knowledge about particular resistance mechanisms to melanoma treatment.

Cooperation of dermatology and podology

Mgr. Jaroslav Fešar, MBA

Dermatol. praxi. 2024;18(1):35-38 | DOI: 10.36290/der.2024.005  

Dermatology and podology are two distinct but interrelated fields where skin and nails are of common interest. In the Czech Republic, podology is defined as preventive and reconditioning care for the feet, which is provided mainly in chiropody facilities. Its basis is top-notch chiropody expertise, which is followed by superstructure knowledge and skills. The article offers an insight into the cooperation between a chiropodist specializing in podology and a dermatologist, which has been developed for a long time and works well in practice.

Morbus Hailey-Hailey

MUDr. Eliška Langerová

Dermatol. praxi. 2024;18(1):39-43 | DOI: 10.36290/der.2024.006  

Morbus Hailey-Hailey, benign familiar pemfigus, is a chronic autosomal dominant acantholytic dermatosis, which is characterised by flaccid bullae in the intergtriginous areas that rupture easily. In chronic lesions appear erythematous plaques, moist vege­tations, painful fissures and lesions are malodorous. Disease has relapsing-remitting course, with worsening during the summer. Trigger factors are UV light, friction, sweating, infection, stress, hormonal changes. It affects mainly people in their 30´s-40´s, without sex or racial predominance. Positive family history is in 70 % of cases. Defect in ATP2C1 gene, localised at 3^rd chromosome...

Bimekizumab in patient with psoriasis and psoriatic arthritis

MUDr. Marie Jandová, Ph.D.

Dermatol. praxi. 2024;18(1):44-47 | DOI: 10.36290/der.2024.007  

We present a case report of a 69-year-old female patient with psoriasis and psoriatic arthritis, who has been treated with several biological agents since 2007. Currently, she is taking bimekizumab with excellent efficacy on skin manifestations, but with inadequate effect on joint issues.

Possibilities of pharmacological and surgical treatment of hidradenitis suppurativa

MUDr. Júlia Bartková, MBA, Ema Šutaková, Miroslava Verbat, Dominika Miklišová, prof. MUDr. Břetislav Lipový, Ph.D., MBA, LL.M.

Dermatol. praxi. 2024;18(1):48-51 | DOI: 10.36290/der.2024.008  

Hidradenitis suppurativa (HS) is difficult to diagnose and often refractory to conventional treatment which make its treatment and management very challenging for clinicians. The treatment option can vary according to the stage of the disease. For each patient, proper education is recommended, including options for conservative treatment, psychosocial support, options for pain relief, and treatment of suppurative manifestations with the application of appropriate wound coverage. To achieve minimal recurrence, surgical therapy has its place at every stage of the disease. A multidisciplinary approach including mainly dermatologist and plastic surgeon...

Taking care of sensitive skin in children

MUDr. Helena Michalíková

Dermatol. praxi. 2024;18(1):52-55  

Children's skin is both structurally and functionally different from that of adults. After birth, there are rapid changes associated with maturation of the barrier function in particular, but at the same time the skin immune system is formed, melanogenesis occurs, and so on. Children's skin is softer, more sensitive, and more permeable. There is a risk of increased absorption and, thus, even of toxic action of some compounds (e. g., salicylic acid). Therefore, the care of children's skin and choice of appropriate products should be given particular attention.

Vybrané poznatky z 32. kongresu Evropské akademie dermatovenerologie (EADV), Berlín, 11.-14. 10. 2023

doc. MUDr. Karel Ettler, CSc.

Dermatol. praxi. 2024;18(1):56-58