Dermatol. praxi. 2009;3(3):109-118 [Klin Farmakol Farm. 2008;22(2):72-80]

Current therapy of skin and mucosal mycoses

doc. RNDr. Vladimír Buchta CSc^2,1, doc. MUDr. Radovan Slezák CSc³, doc. MUDr. Jiří Špaček, Ph.D⁴, MUDr. Marie Košťálová, Ph.D⁵, Mgr. Marcela Vejsková^2,1, doc. PharmDr. Martin Doležal Ph.D^7,6

¹ Katedra biologických a lékařských věd, Farmaceutická fakulta UK v Hradci Králové

² Ústav klinické mikrobiologie FN a LF UK Hradec Králové

³ Stomatologická klinika LF UK a FN v Hradci Králové

⁴ Porodnická a gynekologická klinika, LF UK a FN v Hradci Králové

⁵ Klinika nemocí kožních a pohlavních, LF UK a FN v Hradci Králové

⁶ Farmaceutická fakulta, Hradec Králové

⁷ _

Superficial fungal infections are common, particularly dermatophytoses, onychomycoses, and vulvovaginal Candida infections. Most of

these mycoses are treated with topical antimycotic drugs unless the infection involves an extensive area or is resistant to initial therapy.

The use of griseofulvin in dermatology is limited to a few indications (tinea capitis in children), ketoconazole is replaced by other triazole

drugs with a better pharmacological profile (no risk of idiopathic hepatitis) in most indications. Onychomycosis – one of the most difficultto-

treat dermatomycosis largely requires systemic therapy with terbinafine or itraconazole which can be combined with topical drugs

such as amorolfine and ciclopirox olamine. Fluconazole is a drug of choice in the majority of cases of oropharyngeal and vulvovaginal

infections caused by Candida albicans and other susceptible yeasts. The therapeutic regimen of refractory mucosal mycoses should be

modified in terms of dosage, duration of therapy, and choice of an adequate antifungal drug according to etiological agents and/or immune

status of the patient. The goal of this review is to provide an overview of currently available therapeutic options for the treatment

of common skin and mucosal fungal infections.

Keywords: therapy, fungi, skin infections, onychomycosis, antifungals, therapy, dermatophytes, yeasts.

Published: June 1, 2009  Show citation