Dermatol. praxi. 2020;14(1):36-38 | DOI: 10.36290/der.2020.002

Mouth ulcer as a side effect of methotrexate therapy

MUDr. Lucie Zgažarová

Kožní oddělení, Masarykova nemocnice Ústí nad Labem

Following case report describes the case of the patient with two month lasting progressive lesion of the lower lip, which was histologically verified as the EBV positive mucocutaneous ulcer corresponding with long-term use of methotrexat. Mucocutaneous ulcer induced by the EBV infection is a rare clinical-pathological unit connected with imunosuppression of various etiology, here an important role has also an age-related immunosenescence. It is characterized by localy isolated cutaneous and mucosal lesion, it has indolent behavior and limited clinical course. Determination of the correct diagnosis is based on anamnestic data, clinical course and specific histological picture. In the diagnosis of non-specific ulcers is appropriate to investigate the presence of EBV virus, either by immunohistochemistry or by in situ hybridization. The disease prognosis has been favorable so far in most patients, with lesion regression after discontinuation of immunosuppressive therapy.

Keywords: ulcer, EBV, mucocutaneous, methotrexate, immunosuppression.

Published: March 25, 2020  Show citation