Dermatol. praxi. 2020;14(3):136-141 | DOI: 10.36290/der.2020.025

Skin changes in diabetic patients

MUDr. Pavlína Piťhová, Ph.D.1, MUDr. Lucie Růžičková Jarešová2
1 Interní klinika 2. LF UK a FN Motol, Praha
2 L‑DermaMedEst, Praha

Skin changes could develope in 25-50% of diabetic patients during their life span. Skin changes are divided in lesions related to bad metabolic control disappearing after improvement of metabolic control (pruritus, skin infections), lesions not related to metabolic control (macrovascular and microvascular complications) and skin lesions resulting from diabetes therapy (allergic skin lesions, lipodystrophy). This article discusses ethiology, pathogenesis and clinical manifestation of the most frequently observed skin changes in diabetic patients.

Keywords: diabetes mellitus, pruritus, skin infection, necrobiosis lipoidica, acanthosis nigricans, lipodystrophy.

Published: October 20, 2020  Show citation

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Piťhová P, Růžičková Jarešová L. Skin changes in diabetic patients. Dermatol. praxi. 2020;14(3):136-141. doi: 10.36290/der.2020.025.
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    References

    1. Bustan RS, Wasim D, Yderstraede KB, Bygum A. Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review. Dan Med J. 2017; 64: A5316. Go to PubMed...
    2. González‑Saldivar G. Skin manifestations of insulin resistance: from a biochemical stance to a clinical diagnosis and management. Dermatol Ther. 2017; 7: 37-51. Go to original source...
    3. de Macedo GMC, Nunes S et Barreto T. Skin disorders in diabetes mellitus: an epidemiology and physiopathology review. Diabetol Metab Syndr 2016; 8: 63. doi: 10.1186/s13098-016-0176-y Go to original source... Go to PubMed...
    4. Eaglstein WH, Callen JP. Dermatologic comorbidities of diabetes mellitus and related issues. Arch Dermatol. 2009; 145: 467-469. Go to original source... Go to PubMed...
    5. Clerc C‑J, Misery L. A literature review of senile pruritus: From diagnosis to treatment. Acta Dermato‑Venereologica 2017; 97(4): 433-440. Go to original source...
    6. Neilly JB, Martin A, Simpson N, et al. Pruritus in diabetes mellitus: investigation of prevalence and correlation with diabetes control. Diab Care 1986; 9: 273-275. Go to original source...
    7. Holdiness MR. Management of cutaneous erythrasma. Drugs. 2002; 62: 1131-1141. Go to original source... Go to PubMed...
    8. Dryden M, Baguneid M, Eckmann C, Corman S, Stephens J, Solem C, et al. Pathophysiology and burden of infection in patients with diabetes mellitus and peripheral vascular disease: focus on skin and soft‑tissue infections. Clin Microbiol Infect. 2015; 21: S27-S32. Go to original source... Go to PubMed...
    9. Kalra S, Chawla A. Diabetes and balanoposthitis. J Pak Med Assoc. 2016; 66: 1039-1041. Go to PubMed...
    10. Papini M, Cicoletti M, Fabrizi V, Landucci P. Skin and nail mycoses in patients with diabetic foot. G Ital Dermatol Venereol. 2013; 148: 603-608.
    11. Jirkovská A, et al. Syndrom diabetické nohy: komplexní týmová péče. Praha: Maxdorf, 2006. Jessenius.
    12. Guidelines IWGDF 2019. Dostupná z: https://iwgdfguidelines.org/guidelines/guidelines/
    13. Avist J, Elgzyri T, Larsson J, et al. Factors related to outcome of neuroischemic/ischemic foot ulcer in diabetic patients. J Vasc Surg 2011; 53: 1582-1588 Go to original source...
    14. Meloni M, Izzo V, Giurato L, Gandini R, Uccioli L. Below‑the‑ankle arterial disease severely impairs the outcomes of diabetic patients with ischemic foot ulcers. Diabetes Res Clin Pract. 2019 Jun; 152: 9-15. doi: 10.1016/j.diabres.2019. 04. 031. Go to original source...
    15. Fejfarová V, Jirkovská A, et al. Léčba syndromu diabetické nohy odlehčením. Praha: Maxdorf, 2015.
    16. Boulton AJM, Armstrong DG, Kirsner RS, Attinger CE, et al. Diagnosis and Management of Diabetic Foot Complications. Arlington (VA): American Diabetes Association; 2018 Oct. Go to original source...
    17. Morgan AJ, Schwartz RA. Diabetic dermopathy: a subtle sign with grave implications. J Am Acad Dermatol. 2008; 58: 447-451. Go to original source... Go to PubMed...
    18. Reid SD, Ladizinski B, Lee K, et al. Update on necrobiosis lipoidica: a review of etiology, diagnosis, and treatment options. J Am Acad Dermatol 2013; 69: 783-791.Další literatura u autorky a na www.dermatologiepropraxi.cz Go to original source... Go to PubMed...
    19. Boateng B, Hiller D, Albrecht HP, et al. Cutaneous microcirculation in pretibial necrobiosis lipoidica. Comparative measurements of laser doppler flux and partial pressure of oxygen in patients and in healthy volunteers. Hautarzt 1993; 44: 581-586. Go to PubMed...
    20. Thornsberry LA, English JC 3rd. Etiology, diagnosis, and therapeutic management of granuloma annulare: an update. Am J Clin Dermatol. 2013; 14: 279-290. Go to original source...
    21. Gupta V, Gulati N, Bahl J, Bajwa J, Dhawan N. Bullosis diabeticorum: rare presentation in a common disease. Case Rep Endocrinol. 2014; 2014: 862912. Go to original source...
    22. Lopez PR, Leicht S, Sigmon JR, Stigall L. Bullosis diabeticorum associated with a prediabetic state. South Med J. 2009; 102: 643-644. Go to original source... Go to PubMed...
    23. Namazi MR, Jorizzo JL, Fallahzadeh MK. Rubeosis faciei diabeticorum: a common, but often unnoticed, clinical manifestation of diabetes mellitus. Scientific World Journal. 2010; 10: 70-71. Go to original source... Go to PubMed...
    24. Higgins ST, Fremark M, Prose NS. Acanthosis nigricans: a practical approach to evaluation and management. Dermatol Online J. 2008; 14: 2. Go to original source...
    25. Shah R, Jindal A, Patel N. Acrochordons as a cutaneous sign of metabolic syndrome: a case‑control study. Ann Med Health Sci Res. 2014; 4: 202-205. Go to original source...

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