Dermatol. praxi. 2020;14(3):142-146 | DOI: 10.36290/der.2020.026

Manifestations of psoriatic arthritis in patients with psoriasis

MUDr. Martina Skácelová, Ph.D., prof. MUDr. Pavel Horák, CSc.

III. interní klinika - nefrologická, revmatologická a endokrinologická, LF a UP Olomouc

Psoriatic arthritis is a severe chronic musculoskeletal disorder associated with psoriasis. In accordance to main clinical manifestations it can be divided into 5 subgroups (oligoarticular, polyarticular, DIP involvement, arthritis mutilans and axial form). Untreated or long term active disease can lead to severe destructive joint involvement, disability and progress of comorbidities. The CASPAR classification criteria are used in diagnosis, therapy is managed by the EULAR and GRAPPA recommendations. The approach to the patient is multidiciplinal, the first choice drug is methotrexate or other synthetic disease modifying drug, biologic treatment (TNF α, IL-12/23 or IL-17 inhibitors) is indicated in the case of inadequate therapeutic response, in the case of biologic treatment failure or contraindications inhibitors of PDE-4 are used.

Keywords: psoriasis, psoriatic arthritis, CASPAR criteria, methotrexate, biologic treatment.

Published: October 20, 2020  Show citation