Dermatol. praxi. 2022;16(4):199-203 | DOI: 10.36290/der.2022.040

Diagnosis of autoimmune bullous diseases

prof. MUDr. Hana Jedličková, Ph.D.
Dermatovenerologická klinika FN u sv. Anny v Brně a LF MU, Brno

Autoimmune blistering diseases are rare organ-specific autoimmune diseases characterized by autoantibodies against desmosomal and hemidesmosomal adhesive proteins of epidermis. They can be divided into two main groups - pemphigus group with intraepidermal blisters and pemphigoid group with subepidermal blisters. Correct diagnosis of the subtypes is based on a complex of clinical observation, histopatological and immunofluorescence examinations, detection of circulating autoantibodies by indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and immunoblotting, thus allowing the precise diagnosis and the choice of appropriate therapy.

Keywords: pemphigus, pemphigoid, histology, immunofluorescence, ELISA.

Accepted: November 29, 2022; Published: December 1, 2022  Show citation

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Jedličková H. Diagnosis of autoimmune bullous diseases. Dermatol. praxi. 2022;16(4):199-203. doi: 10.36290/der.2022.040.
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