Syndrom vyhoření: změna paradigmatu

Mgr. et Mgr. Marek Vácha, Ph.D.

Dermatol. praxi. 2024;18(3):127

Microbiome in atopic eczema in practice

MUDr. Nina Benáková, Ph.D.

Dermatol. praxi. 2024;18(3):130-134 | DOI: 10.36290/der.2024.026

Skin barrier, skin microbiome, components of non-specific and specific skin immunity build physiologically a functional complex. Therapeutic and preventive management of atopic eczema by restoring proper skin microbiome is a potential way for adjunction to existing therapeutic options. However, it has its pitfalls as the skin microbiome is individually specific and variable over time. In practice, postbiotics in special emollients are the closest to this aim, so far.

Bimekizumab efficacy though 144 weeks in moderate to severe plaque psoriasis: results documented patients from the BE RADIANT study

doc. MUDr. Miloslav Salavec, CSc.

Dermatol. praxi. 2024;18(3):135-139 | DOI: 10.36290/der.2024.027

Bimekizumab is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A . Such therapy is indicated in adult patients with moderate to severe plaque psoriasis requring systemic form of treatment. This article reviews the impact of bimekizumab on patient-reported itching, skin pain, scaling, and health-related quality of life in patients with moderate to severe plaque psoriasis over 3 years compared to secukinumab managemennt. Included patients reported rapid improvements in reported symptoms and health-related quality of life as early as week 4. High responses observed at week 48 were durable through week 144.

Food allergy and skin

MUDr. Mojmír Račanský

Dermatol. praxi. 2024;18(3):141-146 | DOI: 10.36290/der.2024.028

Food allergy is increasing in prevalence worldwide. It is defined as an undesirable immunological adverse reaction after food ingestion. Acute IgE-mediated allergy is a well-described mechanism of food allergy. However, non-IgE mechanisms are often found. Allergen-specific T-cells and reactions of innate immunity cells play a crucial role in non-IgE reactions. Clinical signs of food allergy are not limited to the gastrointestinal tract. One of the most commonly involved organs is the skin. We can identify acute urticaria, angioedema, or atopic dermatitis flare-ups. Diagnostic options are vast. The first step must be a precise personal history focusing...

Skin care in oncology patients

MUDr. Linda Vavříková, MUDr. Kateřina Libigerová, MUDr. Renáta Kopová

Dermatol. praxi. 2024;18(3):147-150

Skin is the biggest organ that indicates internal diseases. Skin and mucous membrane manifestations can be initial symptoms during serious internal diseases. The number of patients living with cancer has increased, and this is the reason, why the skin deserves specific attention. Dermatologic symptoms are very different. We focus on adverse effects during cancer treatment and skin care.

Treatment of atopic dermatitis

MUDr. Gabriela Takáčová, MBA

Dermatol. praxi. 2024;18(3):151-153 | DOI: 10.36290/der.2024.029

Atopic dermatitis is a chronic inflammatory skin disease with a multifactorial etiology. In most patients, it begins in childhood, in some patients it persists into adulthood. The goal of therapy is to prolong remission. The therapy of atopic dermatitis is complex. We currently have a wide range of topical, physical and systemic treatment options available. The choice of therapy takes into account the stage of the disease, the severity of atopic dermatitis and the individual preference of the patient.

Case report of a patient with skin complications of biological therapy Crohn's disease, successfully treated with risankizumab

MUDr. Jiří Horažďovský, Ph.D.

Dermatol. praxi. 2024;18(3):154-158 | DOI: 10.36290/der.2024.030

Targeted biological therapy has brought about a dramatic change in the treatment of autoimmune inflammatory diseases. The wide spectrum of use of these drugs is associated with a new class of treatment side effects, also sometimes called paradoxical reactions. The target organ of these reactions is very often the skin. The article presents a patient with Crohn's disease, treated with biologics, with the gradual development of 3 skin autoimmune diseases and their successful treatment with risankizumab.

Advancement flap reconstruction after excision of basal cell carcinoma

MUDr. Júlia Bartková, MBA, MPH, Miroslava Verbat, MUDr. Ema Šutáková, MUDr. Dominika Miklišova, Ema Knezovičová, MUDr. Iva Tresnerová, MUDr. Jana Bartošková

Dermatol. praxi. 2024;18(3):159-162 | DOI: 10.36290/der.2024.031

Skin cancer remains a significant public health concern, imposing a substantial burden on healthcare systems worldwide. With its high incidence rates continuously driving up healthcare costs, there is a pressing need to prioritize the improvement of preventive programs dedicated to combating this growing problem. Enhancing preventive measures is paramount in alleviating the strain placed on healthcare systems by skin cancer. By promoting awareness of risk factors, advocating for early detection practices, and encouraging UV-safe behaviors, preventive initiatives empower individuals to take proactive steps in safeguarding their skin health. The case...

Vascular complications and hyaluronidase

MUDr. Kateřina Klauzová, MBA

Dermatol. praxi. 2024;18(3):163-166 | DOI: 10.36290/der.2024.032

The application of filler material, particularly in the facial area, is a popular aesthetic procedure used to restore volume, improve contours and smooth wrinkles. Hyaluronic acid is considered the safest option, but it too carries the risk of vascular complications. These complications can be severe and lead to ischemia, tissue necrosis, or even blindness or stroke. This article focuses on identifying the risks associated with vascular complications associated with dermal filler application and strategies for prevention and management.