Immunotherapy in non-melanoma skin cancerReview articles

MUDr. Miroslav Důra, Ph.D.

Dermatol. praxi. 2023;17(1):20-25  

Antitumoral immunotherapy is a golden standard in modern therapy in the increasing number of metastatic or locally advanced solid tumors. This treatment achieves significant and long-lasting treatment responses and reveals prolongation of progression free survival, overall survival, together with quality-of-life improvement. In the field of malignant cutaneous tumors, the therapeutic effect of immunotherapy is well-known in metastatic melanoma, in which the immunotherapy became a standard of the modern systemic treatment. The effect of the immunotherapeutic drugs was also established in metastatic and locally advanced non-melanoma skin cancer, namely...

Immunopathological inflammation in patients with psoriasis is effectively reduced by bimekizumab treatment targeting simultaneously IL-17A and IL-17FReview articles

prof. RNDr. Jan Krejsek, CSc.

Dermatol. praxi. 2023;17(1):16-19 | DOI: 10.36290/der.2023.003  

Immunopathological inflammation in psoriasis patients is probably initiated in skin by the presence of damage associated patterns and/or patterns of microbial invasion. These patterns are identified by receptors with subsequent activation of downstream signalling pathways ultimating in transcription of several hundreds proinflammatory genes in innate immunity cells and keratinocytes. Abnormal functional polarisation of T cells into Th17 subset is mediated by regulatory axis IL-12/IL-23. T cells of Th17 subset, TcRγδ T cells, ILC3 cells and keratinocytes are rich source of IL-17A and IL-17F interleukines which playing the substantial role...

Gender reassignment and successful biological treatment of severe atopic dermatitisReview articles

MUDr. Monika Hudymačová

Dermatol. praxi. 2023;17(1):13-15 | DOI: 10.36290/der.2023.002  

We present the case of a young man suffering from severe atopic dermatitis, who also underwent gender reassignment from female to male. In addition, within the period of exacerbation of AD, the clinical picture of erythroderma with generalized lymphadenopathy mimics hemato-oncological disease. Conventional therapy with immunosuppressants and corticoids was accompanied by adverse effects and was unsuitable for further planned plastic surgeries for gender reassignment. The only effective treatment for the patient is biological therapy with dupilumab.

Care for children with epidermolysis bullosaReview articles

Mgr. Petra Šimánková

Dermatol. praxi. 2023;17(1):8-12 | DOI: 10.36290/der.2023.001  

Children with epidermolysis bullosa (EB) are a rare population with high morbidity and mortality. EB has a profound impact on the daily life of the patient and family members, on the child's physical, psychological and mental health, including disruption of social relationships. It is common for EB patients to be cared for by health professionals who are not specialized in this rare disorder. Health professionals educate parents about safety and preventive steps in caring for a child with EB, how to treat the child, how to recognize the characteristics of a wound, how to care for wounds, how to breastfeed and feed the child, etc. Increasing the knowledge...

Abstrakta
14. KONFERENCE DERMATOLOGIE PRO PRAXI – OlomoucAbstracts

redakce

Dermatol. praxi 2022; 16(Suppl.A)  

Sdělování špatné zprávy (1. část)Editorial

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2022;16(4):187  

Case of the Lyme disease in winter monthsCase report

MUDr. Tereza Zedníčková, MUDr. Veronika Paťavová

Dermatol. praxi. 2022;16(4):225-227  

Lyme disease is the most common infectious disease transmitted by ticks in the Czech Republic. It is a zoonosis caused by spirochetes of the genus Borrelia. At greatest risk of disease are children between 5 to 9 years and adults over 55 years. Clinical skin manifestations of lyme disease are divided into three stages: Localised Lyme disease, Early disseminated Lyme disease, both a and Late Lyme disease, which occur months or years after infection. Lyme disease can also affect other part of the body like central nervous system, musculoskeletal system, heart, the eyes and other organs. 

Medical cannabis and its potential use in dermatologyInterdisciplinary overviews

PharmDr. Jaroslav Peč, Ph.D., Mgr. Dominika Kaczorová, Mgr. Tibor Béres, Ph.D., doc. RNDr. Petr Tarkowski, Ph.D., PharmDr. Jaroslav Matal, Ph.D.

Dermatol. praxi. 2022;16(4):217-220  

Cannabis for medical use has been successfully incorporated into Czech clinical practice, especially in the fields of algesiology and neurology. Under the current legislation, medical cannabis can also be used in dermatology in the indication surface treatment of dermatoses and mucosal lesions. However, this use is so far neglected, mainly due to the lack of a standardized procedure for the preparation of dermal dosage forms in pharmacies and also due to the unavailability of standardized medicinal cannabis extracts, which are available abroad. However, influencing the endocannabinoid system topically at the skin level provides an interesting pharmacological...

Oily skin and acne – what to recommend in a pharmacy?Interdisciplinary overviews

PharmDr. Miroslava Pavelková, Ph.D.

Dermatol. praxi. 2022;16(4):212-216  

There is with acne a primarily oily type of skin. The recommended approach to oily skin and acne therefore overlaps. A common feature is targeting key factors (sebum overproduction, follicular hyperkeratinization, increased colonization of Cutibacterium acnes, and inflammation) that contribute to varying degrees in the acne´s pathogenesis. The role of professional staff at a pharmacy is to recommend how to properly care for oily/acne-prone skin and to advise in a selection of an appropriate (cosmetic) product, which must be irritant-free and without comedogenic substances.

Zpráva z 16. konference akné a obličejové dermatózyInformation

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2022;16(4):237-238  

Některé poznatky z 28. Fortbildungswoche für praktische Dermatologie und Venerologie 2022 (FOBI) - 13.-16. 7. 2022Information

doc. MUDr. Karel Ettler, CSc.

Dermatol. praxi. 2022;16(4):235-236  

Bimekizumab - new biological drug in the treatment of psoriasisPharmacological profile

MUDr. Jan Šternberský, Ph.D., MUDr. Martin Tichý, Ph.D.

Dermatol. praxi. 2022;16(4):231-234 | DOI: 10.36290/der.2022.047  

In the therapy of psoriasis, we have a whole range of very effective biological drugs available on our market. Bimekizumab, an inhibitor of interleukin 17 (IL-17), is a new preparation that expands our options for the effective treatment of moderate to severe forms of chronic plaque psoriasis in adult patients. Bimekizumab has demonstrated its high effectiveness, rapid onset of action and favorable safety profile in a number of clinical studies.

Platelet-rich plasma and topical finasteride for androgenic alopecia: a case studyCase report

MUDr. Markéta Fridman

Dermatol. praxi. 2022;16(4):228-230 | DOI: 10.36290/der.2022.046  

Androgenic alopecia is a common hair loss disorder caused by genetic and hormonal factors that are characterized by androgen-related progressive thinning of scalp hair in a defined pattern. First-line therapy for androgenic alopecia is topical minoxidil but due to its limited effect platelet-rich plasma (PRP) has become an effective alternative treatment. This case study presents a 35 year old male with androgenic alopecia treated with topical minoxidil for 3 years with minimal results. After 2 applications of PRP treatment with concomitant topical minoxidil and topical finasteride significant regrowth was seen within 3 months. This combined treatment...

Genital lymphedemaCase report

MUDr. Naděžda Vojáčková

Dermatol. praxi. 2022;16(4):221-224 | DOI: 10.36290/der.2022.044  

genital lymphedema is a rare condition but it substantially impairs quality of life. Isolated genital lymphedema can occur, frequently it is together with lymphedema of the lower extremities. Genital lymphedema is classified as primary or secondary disorder. The investigation includes history, blood tests, venereology testing, lymphoscintigraphy, X-ray of the lungs, MRI, colonoscopy, skin biopsy. The therapy is a conservative, surgical or combined therapy. The conservative therapy is the complex decongesive therapy which is more diffucult due to the localisation. The most common surgical therapy is the resectional procedure of the abdomen wall, scrotum,...

Adverse effects of systemically administered drugs on the skinReview articles

doc. MUDr. Karel Ettler, CSc.

Dermatol. praxi. 2022;16(4):205-210 | DOI: 10.36290/der.2022.041  

Adverse effects of systemic therapy can also be observed on the skin. Pharmacological (predictable) and idiosyncratic (unpredictable) responses are distinguished. Drug allergy is also included here, most often type IV (e. g., toxic epidermal necrolysis). The temporal relationship between an adverse reaction and drug intake is important for establishing the diagnosis; laboratory tests and in-vivo exposure tests are used for confirmation. Treatment measures primarily include discontinuing the suspected medication. In addition, topical dermatological treatment and, in more severe cases, systemic therapy can be provided (antihistamines, corticoids, and/or...

Diagnosis of autoimmune bullous diseasesReview articles

prof. MUDr. Hana Jedličková, Ph.D.

Dermatol. praxi. 2022;16(4):199-203 | DOI: 10.36290/der.2022.040  

Autoimmune blistering diseases are rare organ-specific autoimmune diseases characterized by autoantibodies against desmosomal and hemidesmosomal adhesive proteins of epidermis. They can be divided into two main groups - pemphigus group with intraepidermal blisters and pemphigoid group with subepidermal blisters. Correct diagnosis of the subtypes is based on a complex of clinical observation, histopatological and immunofluorescence examinations, detection of circulating autoantibodies by indirect immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and immunoblotting, thus allowing the precise diagnosis and the choice of appropriate therapy.

The present and future of enzybiotics in the therapy of infectious complications in the burned area caused by Staphylococcus aureus strainsReview articles

MUDr. Filip Raška, doc. MUDr. Břetislav Lipový, Ph.D., MBA, LL.M., Mgr. Šárka Kobzová, Mgr. Lukáš Vacek, RNDr. Lubomír Janda, Ph.D.

Dermatol. praxi. 2022;16(4):195-198 | DOI: 10.36290/der.2022.039  

Even today, infectious complications in patients with thermal injury represent a complex issue, which significantly increases the morbidity and mortality of severely burned patients. Colonization and infection in the burned area are most often caused by various strains of Staphylococcus aureus. Due to the strong selection pressure of topically or systemically administered antimicrobial preparations, several multiresistant variants have developed over time in this pathogen. This fact leads to efforts to find other effective preparations in the fight against pathogenic microorganisms. One of the most promising possibilities appears to be the use...

The News in a Treatment of Severe Forms of AcneReview articles

MUDr. Zuzana Nevoralová, Ph.D.

Dermatol. praxi. 2022;16(4):190-194 | DOI: 10.36290/der.2022.038  

In the first part of the article, a term severe acne is identified. Acne fulminans and acne fulminans sine fulminans are described in detail. There exist a recommendation for a treatment of severe forms od acne from 2016, peroral isotretinoin is a primary medicine in a treatment. This fact is valid till now but some recommendations for a treatment with this medicine have changed. There are especially a daily recommended dose (lower doses are prefered now), a length of a treatment (not a total cumulative dose but a length of a treatment after patient´s healing is important ) and a possibility of prevention of isotretinoin induced acne fulminans. Later,...

Risankizumab v terapii psoriatické artritidyZaznělo na kongrese

MUDr. Eva Gavendová

Dermatol. praxi. 2022;16(3):175-176  

Proč přibývá stresu?Editorial

MUDr. Radkin Honzák, CSc.

Dermatol. praxi. 2022;16(3):123  

Biologická léčba psoriázy - účinná metoda, o které většina pacientů nevíDialogue

doc. MUDr. Spyridon Gkalpakiotis, Ph.D., MBA

Dermatol. praxi. 2022;16(3):180-182  

Chronická spontánní kopřivka jako autoimunitní onemocněníZaznělo na kongrese

MUDr. Iva Karlová

Dermatol. praxi. 2022;16(3):178-179  

Collagen and its use in dermatologyCosmetic dermatology spot

MUDr. Martina Matzenauer

Dermatol. praxi. 2022;16(3):171-174 | DOI: 10.36290/der.2022.035  

Aging is an inevitable process that none of us can avoid. With advancing age and mainly as a result of the times we live in, younger and younger groups of people are interested in improving their appearance and rejuvenation, especially in the facial area. Hand in hand with this interest goes the market, which offers a variety of support products and products that promise firmer, more flexible and, above all, more beautiful skin without wrinkles. Collagen in various forms, whether oral or in the form of creams, has enjoyed the greatest interest in recent years, thanks in no small part to the influence of advertising in the media and on social networks....

Current Role of 5-fluorouracil in the Treatment of Actinic KeratosisPharmacological profile

doc. MUDr. Jiří Slíva, Ph.D.

Dermatol. praxi. 2022;16(3):167-170 | DOI: 10.36290/der.2022.034  

Actinic keratosis is the most common skin precancerosis that occurs on skin damaged by chronic exposure to ultraviolet radiation, hence the synonym "solar keratosis". The range of treatment options is relatively strict, but in addition to surgery and cryotherapy, it includes topical pharmacotherapy. The article summarizes the basic observations of the treatment options and focuses mainly on the benefits of 5-fluorouracil in 5% and the innovative 4% form of the cream.

The Use of Topical JAK Inhibitors in DermatologyPharmacological profile

MUDr. Petra Matalová, Ph.D., MUC. Karolína Šimková

Dermatol. praxi. 2022;16(3):164-166 | DOI: 10.36290/der.2022.033  

The JAK/STAT signaling pathway is activated by a number of cytokines and growth factors. Drugs known as JAK inhibitors (JAKi) target cytokine signalization by either oral or topical administration. Topical application can minimize the risk of side effects observed with systemic application. The following article discusses different skin diseases in which local JAKi have positive therapeutic effect. Their use also reduces the risk of side effects of immunosuppressants and local corticosteroids.

Lymphoepithelioma-like carcinoma of the skinCase report

MUDr. Ľudmila Michnová, MUDr. Eva Traboulsi

Dermatol. praxi. 2022;16(3):161-162 | DOI: 10.36290/der.2022.032  

Lymhoepithelioma-like carcinoma of the skin (LELCS) is an extremely rare tumor morphologically similar to undifferentiated nasopharyngeal carcinoma. The presence of this type of tumor has been described in skin areas exposed to the sun, more often in the elderly in the age of 70, manifests as a solitary nodule. LELCS has very good prognosis, most patients are cured by local excision.

An unussual type of bullous diseaseCase report

MUDr. Eva Valihrachová

Dermatol. praxi. 2022;16(3):157-159 | DOI: 10.36290/der.2022.031  

Next case report describes 57 year old patient with personal history of lichen ruber planus, who suddenly developed bullous diseae.

Severe form of atopic dermatitis in a boy with liver transplant and two subsequent retransplantionsCase report

MUDr. Štěpánka Čapková

Dermatol. praxi. 2022;16(3):153-156 | DOI: 10.36290/der.2022.030  

There is a lack of literature regarding the treatment of atopic dermatitis (AD) in patients with organ transplants. Despite the immunosuppressive regiments in the post-transplant population, de novo development of AD is well- documented phenomenon, particularly in liver transplant recipients. We report a case of dupilumab treatment in a liver transplant adolescent with severe AD under immunosuppressive therapy with tacrolimus.

Rigid nodules in the umbilical regionCase report

MUDr. Irina Afanasyeva, doc. MUDr. Spyridon Gkalpakiotis, Ph.D., MBA, MUDr. Václav Eis, Ph.D., MUDr. Jan Hugo

Dermatol. praxi. 2022;16(3):150-152 | DOI: 10.36290/der.2022.029  

This case report describes a 65-year-old man with new lesions in the umbilical region. Based on histopathological examination, it was found to be "Sister Mary Joseph's nodules", metastases of poorly differentiated pancreatic cancer.

Ageing woman at dermatologyInterdisciplinary overviews

doc. MUDr. Tomáš Fait, Ph.D.

Dermatol. praxi. 2022;16(3):145-149 | DOI: 10.36290/der.2022.028  

Menopause is conected and based on hard fall of the estrogen selfproduction. It induce negative changes in skin. Protective effects of any systemic estrogene therapy is clear and evidence-based. Hormone replacement therapy´s indication is temporary, it is why role of special cosmetics for ageing skin could not be ignore.